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Drugs-From Discovery to Approval Rick Ng
Publisher: Wiley-Liss

Ng R., Drugs: from Discovery to Approval (2004) http://www.pharmatext.org/2008/06/drugs-from-discovery-to-approval.html. This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. Although arsphenamine was used to treat many syphilitic patients, .. It represents a potential new target to go after. Seven of the approved drugs offer treatment for conditions where there was no real previous options – and therefore represent unambiguous and significant patient benefit. Every country has its own regulatory authority, which is responsible to .. 3.Wang H., Wang C.,Yu W., Hsu S, Huang Y, Lin Y., Leu Y. Your most-cited papers are on a relatively new drug called bevacizumab. In general, a drug approval process comprises of various stages: application to conduct clinical trials, conducting clinical trials, application to marketing authorization of drug and post-marketing studies. Some attack them for slowing down or impeding drug approvals, while others accuse them of safety lapses. There are two drugs from the 1960s that are approved for malignant glioma, carmustine (BCNU) and procarbazine. Food and Drug Administration (FDA) officials are being assailed by the citizenry they serve. At the time syphilis was a fatal and incurable sexually transmitted infection, just as AIDS is today, and so the discovery of an effective treatment had a huge impact on the medical community3. To get approval from the FDA, the clinical trials must show superiority to drugs already on the market and this is extremely difficult to demonstrate [13]. What were you reporting in these studies and what does this drug That was a major discovery, new mutations that had not been seen before in gliomas at all stages— low grade through high grade. Most strikingly, though, five of these seven were in indications that are not just orphan but Academic laboratories, small biotech and global pharma companies contributed almost equal proportions of the real discovery. Browse our cover archive and explore back issues of the Condé Nast Traveler magazine.